The trusted partner for RNA success
Eclipsebio supports RNA discovery and development through integrated design, analytics, and characterization. From therapeutics and oligonucleotides to small molecules and basic research, we deliver the insights needed to advance programs with confidence.
Our other RNA solutions:
Beyond RNA therapeutics, we also offer integrative solutions that support RNA-targeting modalities, AI-driven discovery, and fundamental RNA research
AI Training Data
To support accurate AI model training for drug discovery, we provide high-quality, reproducible datasets through our eVERSE platform.
Small Oligonucleotides
With our holistic approach to small oligonucleotide design and validation, we provide RNAi and ASO developers with the data needed for clinical success. Learn how we perform multiomic profiling of targets and robustly measure off-target effects.
Small Molecules
Our integrative portfolio of assays reveals disease-specific, accessible regions of target RNAs and provides deep profiling of on-target and off-target therapeutic effects.
Basic Research
For our academic partners, we provide a la carte and integrative solutions that deliver a comprehensive view of RNA biology, from secondary structure to protein regulation.
Our capabilities
Comprehensive technologies for unmatched insights
Our portfolio of proprietary technologies and bioinformatics workflows provide actionable insights into all major dimensions of RNA and therapeutic biology.
End-Seq
Map unique regulatory regions
eRibo Pro
Measure transcription and translation
eSENSE dsRNA
Measure and reduce dsRNA contamination
eSENSE m6A
Map regions of RNA methylation
eSHAPE
Directly determine RNA structure
m6A-eCLIP
Locate specific methylated bases
miR-eCLIP+
Identify miRNA binding and siRNA off-targets
Nanopore
Long-read RNA sequencing
RBP-eCLIP
Identify where and how proteins bind
What Our Partners
and Collaborators Say
"Eclipsebio’s analysis of RNA folding has provided valuable insights necessary to understand the impact of RNA sequence and chemical modifications on secondary structures… to help improve the design of our RNAs and rationalize our internal findings."
"Eclipsebio was the only company that could perform the robust siRNA off-target binding analysis we needed. Their experimental results provided important additional insights into our own internal findings. We look forward to continuing to work with Eclipsebio in the future."
"Eclipsebio has been an invaluable partner to Deep Genomics. They've helped us generate massive miRNA-related datasets for training AI models, and have designed and conducted bespoke assays to illuminate the mechanism underlying some of our lead therapeutic compounds."
"At Acuitas we are interested in how modifications to LNP formulations can impact efficacy and stability. Eclipsebio’s eSHAPE assay has potentially revealed direct correlations between LNP composition and RNA secondary structure, further adding to our understanding of the mechanism of action for RNA-LNP systems."
New at Eclipsebio
Expanding our RNA platform
Eclipsebio has acquired Terrain Bio, bringing RNA design and prototyping together with sequencing-powered analytics to support RNA therapeutics from design through validation.
Discover AI success
Artificial intelligence and machine learning are revolutionizing drug discovery. eVERSE is our portfolio of next-generation sequencing data, tailored for AI model training. Discover how eVERSE provides the data needed for success here.
Learn with our newest blog
Discover how closed-loop RNA development pairs design and sequencing to accelerate better therapeutics.
Find out where we will be next
Our team of RNA experts is presenting at conferences and webinars to highlight the power of RNA solutions for therapeutic success. Discover where we will be discussing our platform and partnership opportunities.